Noted in blue was my drive to work when I first moved to Houston. A couple blocks along Hermann Park, then right onto San Jacinto straight into downtown. What was really great about this drive was that the many, many traffic lights were synchronized so you'd rarely hit more than one on the way!
Points include the Museum of Natural Science, favorite restaurants and bars, the venue (bar) for my wedding reception, plus markers for the home I lived in next in Midtown and my favorite bar next door. Also still on the map are my favorite parks (and nearby grub) in Houston.